Two sample MR report
KANSL1-AS1_Conventional Dendritic Cell against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.0393377 | 1.6089205 | 0.9844379 |
| Weighted median | 3 | -0.0961183 | 0.0470192 | 0.0409303 |
| Inverse variance weighted | 3 | -0.0943986 | 0.0393063 | 0.0163229 |
| Simple mode | 3 | -0.0962808 | 0.0540036 | 0.2165499 |
| Weighted mode | 3 | -0.0962962 | 0.0563404 | 0.2295424 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0033136 | 1 | 0.9540958 |
| Inverse variance weighted | 0.0044855 | 2 | 0.9977598 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0467299 | 1.365077 | 0.9782155 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 4.2e-05 | 0 | TRUE | 0.538994 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
